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Secondary Metabolites with Nitric Oxide Inhibition from Marine-Derived Fungus Alternaria sp. 5102.

ABSTRACT: Two new benzofurans, alternabenzofurans A and B (1 and 2) and two new sesquiterpenoids, alternaterpenoids A and B (3 and 4), along with 18 known polyketides (5-22), were isolated from the marine-derived fungus Alternaria sp. 5102. Their structures were elucidated on the basis of extensive spectroscopic analyses (1D and 2D NMR, HR-ESIMS, and ECD) and X-ray crystallography, as well as the modified Mosher's method. Compounds 2, 3, 5, 7, 9-18, and 20-22 exhibited potent anti-inflammatory activity by inhibiting the production of NO in RAW264.7 cells activated by lipopolysaccharide with IC50 values in the range from 1.3 to 41.1 ?M. Structure-activity relationships of the secondary metabolites were discussed.

SUBMITTER: Chen S 

PROVIDER: S-EPMC7460390 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature

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Secondary Metabolites with Nitric Oxide Inhibition from Marine-Derived Fungus <i>Alternaria</i> sp. 5102.

Chen Senhua S   Deng Yanlian Y   Yan Chong C   Wu Zhenger Z   Guo Heng H   Liu Lan L   Liu Hongju H  

Marine drugs 20200814 8

Two new benzofurans, alternabenzofurans A and B (<b>1</b> and <b>2</b>) and two new sesquiterpenoids, alternaterpenoids A and B (<b>3</b> and <b>4</b>), along with 18 known polyketides (<b>5</b>-<b>22</b>), were isolated from the marine-derived fungus <i>Alternaria</i> sp. 5102. Their structures were elucidated on the basis of extensive spectroscopic analyses (1D and 2D NMR, HR-ESIMS, and ECD) and X-ray crystallography, as well as the modified Mosher's method. Compounds <b>2</b>, <b>3</b>, <b>5<  ...[more]

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