Structures and Bioactivities of Quadrangularisosides A, A₁, B, B₁, B₂, C, C₁, D, D₁-D₄, and E from the Sea Cucumber Colochirus quadrangularis: The First Discovery of the Glycosides, Sulfated by C-4 of the Terminal 3-O-Methylglucose Residue. Synergetic Effect on Colony Formation of Tumor HT-29 Cells of these Glycosides with Radioactive Irradiation.

ABSTRACT: Thirteen new mono-, di-, and trisulfated triterpene glycosides, quadrangularisosides A-D₄ (1-13) have been isolated from the sea cucumber Colochirus quadrangularis, which was collected in Vietnamese waters. The structures of these glycosides were established by 2D NMR spectroscopy and HR-ESI (High Resolution Electrospray Ionization) mass spectrometry. The novel carbohydrate moieties of quadrangularisosides D-D₄ (8-12), belonging to the group D, and quadrangularisoside E (13) contain three sulfate groups, with one of them occupying an unusual position-at C(4) of terminal 3-O-methylglucose residue. Quadrangularisosides A (1) and D₃ (11) as well as quadrangularisosides A₁ (2) and D₄

SUBMITTER: Silchenko AS 

PROVIDER: S-EPMC7460491 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature