SPaCE Swab: Point-of-Care Sensor for Simple and Rapid Detection of Acute Wound Infection.

ABSTRACT: Wound infection is commonly observed after surgery and trauma but is difficult to diagnose and poorly defined in terms of objective clinical parameters. The assumption that bacteria in a wound correlate with infection is false; all wounds contain microorganisms, but not all wounds are clinically infected. This makes it difficult for clinicians to determine true wound infection, especially in wounds with pathogenic biofilms. If an infection is not properly treated, pathogenic virulence factors, such as rhamnolipids from Pseudomonas aeruginosa, can modulate the host immune response and cause tissue breakdown. Life-threatening sepsis can result if the organisms penetrate deep into host tissue. This communication describes the sensor development for five important clinical microbial pat

SUBMITTER: Thet NT 

PROVIDER: S-EPMC7460538 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature