Comparison of Neonatal and Adult Fibrin Clot Properties between Porcine and Human Plasma.

ABSTRACT:

Background

Recent studies suggest that adult-specific treatment options for fibrinogen replacement during bleeding may be less effective in neonates. This is likely due to structural and functional differences found in the fibrin network between adults and neonates. In this investigation, the authors performed a comparative laboratory-based study between immature and adult human and porcine plasma samples in order to determine if piglets are an appropriate animal model of neonatal coagulopathy.

Methods

Adult and neonatal human and porcine plasma samples were collected from the Children's Hospital of Atlanta and North Carolina State University College of Veterinary Medicine, respectively. Clots were formed for analysis and fibrinogen concentration was quantified. Structure wa

SUBMITTER: Nellenbach KA 

PROVIDER: S-EPMC7460720 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature