The effect of maternal poliovirus antibodies on the immune responses of infants to poliovirus vaccines.

ABSTRACT:

Background

Maternal poliovirus antibodies could provide passive immunity to the newborns from poliovirus infection during their first few months of life, but they may impair the immune responses of infants to the poliovirus vaccine as well. In our study, we pooled the data from three clinical trials of the inactivated poliovirus vaccine (IPV) based on Sabin strains to investigate the effect of maternal poliovirus antibodies on the immune responses of infants to poliovirus vaccines.

Methods

There were five groups in the pooled analysis, including low-dose Sabin IPV, medium-dose Sabin IPV, high-dose Sabin IPV, control Sabin IPV, and control Salk IPV groups. We reclassified the infants in different groups according to their maternal poliovirus antibodies by two methods, the fir

SUBMITTER: Jia S 

PROVIDER: S-EPMC7460787 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature