Dietary Phenolics against Breast Cancer. A Critical Evidence-Based Review and Future Perspectives.

ABSTRACT: Breast cancer (BC) is the most common malignancy and the leading cause of cancer-related death in adult women worldwide. Over 85% of BC cases are non-hereditary, caused by modifiable extrinsic factors related to lifestyle, including dietary habits, which play a crucial role in cancer prevention. Although many epidemiological and observational studies have inversely correlated the fruit and vegetable consumption with the BC incidence, the involvement of their phenolic content in this correlation remains contradictory. During decades, wrong approaches that did not consider the bioavailability, metabolism, and breast tissue distribution of dietary phenolics persist behind the large currently existing gap between preclinical and clinical research. In the present review, we provide comprehensiv

SUBMITTER: Avila-Galvez MA 

PROVIDER: S-EPMC7461055 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature