RNA-dependent RNA polymerase, RdRP, a promising therapeutic target for cancer and potentially COVID-19.

ABSTRACT: A recent outbreak of coronavirus disease (COVID-19) caused by the novel severe acute respiratory syndrome coronavirus 2 has driven a global pandemic with catastrophic consequences. The rapid development of promising therapeutic strategies against COVID-19 is keenly anticipated. Family Coronaviridae comprises positive, single-stranded RNA viruses that use RNA-dependent RNA polymerase (RdRP) for viral replication and transcription. As the RdRP of viruses in this family and others plays a pivotal role in infection, it is a promising therapeutic target for developing antiviral agents against them. A critical genetic driver for many cancers is the catalytic subunit of telomerase: human telomerase reverse transcriptase (hTERT), identified initially as an RNA-dependent DNA polymerase. However, ev

SUBMITTER: Machitani M 

PROVIDER: S-EPMC7461281 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature