Effect of nicotine lozenge use prior to smoking cue presentation on craving and withdrawal symptom severity.

ABSTRACT:

Background

Smokers are often advised to use nicotine lozenge after cravings or withdrawal symptoms are present, which may be too late to prevent lapses. This study assesses if lozenge use prior to smoking cue exposure attenuates cue-induced increases in symptom severity.

Methods

In this randomized, cross-over study, participants completed three laboratory sessions at which they proceeded through 4 "rooms" in a virtual reality environment. The first and last "rooms" contained neutral cues and the others contained smoking cues. At one session, a 4 mg nicotine lozenge was not given until after cue exposure (to approximate current use: i.e., after craving and withdrawal symptoms occur). At the other two sessions either a nicotine or placebo lozenge was used 15 min before cue exp

SUBMITTER: Kotlyar M 

PROVIDER: S-EPMC7461336 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature