Potential drug-drug interactions associated with adverse clinical outcomes and abnormal laboratory findings in patients with malaria.

ABSTRACT:

Background

Hospitalized patients with malaria often present with comorbidities or associated complications for which a variety of drugs are prescribed. Multiple drug therapy often leads to drug-drug interactions (DDIs). Therefore, the current study investigated the prevalence, levels, risk factors, clinical relevance, and monitoring parameters/management guidelines of potential DDIs (pDDIs) among inpatients with malaria.

Methods

A retrospective cohort study was carried out at two tertiary care hospitals. A total of 398 patients' profiles were evaluated for pDDIs using the Micromedex Drug-Reax^®. Odds ratios were calculated to identify the strength of association between presence of DDIs and potential risk factors via logistic regression analysis. Further, the clini

SUBMITTER: Noor S 

PROVIDER: S-EPMC7461345 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature