Cytokine release syndrome-associated encephalopathy in patients with COVID-19.

ABSTRACT:

Background and purpose

Neurological manifestations in coronavirus disease (COVID)-2019 may adversely affect clinical outcomes. Severe COVID-19 and uremia are risk factors for neurological complications. However, the lack of insight into their pathogenesis, particularly with respect to the role of the cytokine release syndrome (CRS), is currently hampering effective therapeutic interventions. The aims of this study were to describe the neurological manifestations of patients with COVID-19 and to gain pathophysiological insights with respect to CRS.

Methods

In this longitudinal study, we performed extensive clinical, laboratory and imaging phenotyping in five patients admitted to our renal unit.

Results

Neurological presentation included confusion, tremor, cerebellar at

SUBMITTER: Perrin P 

PROVIDER: S-EPMC7461405 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature