Prognostic and Clinicopathological Significance of MiR-155 in Breast Cancer: A Systematic Review.

ABSTRACT: There is an unmet need for novel non-invasive prognostic molecular tumour markers for breast cancer (BC). Accumulating evidence shows that miR-155 plays a pivotal role in tumorigenesis. Generally, miR-155 is considered an oncogenic miRNA promoting tumour growth, angiogenesis and aggressiveness of BC. Therefore, many researchers have focused on its use as a prognostic biomarker and therapeutic target. However, its prognostic value for BC patients remains controversial. To address this issue, the present systematic review aims to summarize the available evidence and give a picture of a prognostic significance of miR-155 in BC pathology. All eligible studies were searched on PubMed and EMBASE databases through various search strategies. Starting from 289 potential eligible recor

SUBMITTER: Grimaldi AM 

PROVIDER: S-EPMC7461504 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature