Postmortem Kidney Pathology Findings in Patients with COVID-19.

ABSTRACT:

Background

AKI is common among hospitalized patients with coronavirus disease 2019 (COVID-19) and is an independent risk factor for mortality. Although there are numerous potential mechanisms underlying COVID-19-associated AKI, our current knowledge of kidney pathologic findings in COVID-19 is limited.

Methods

We examined the postmortem kidneys from 42 patients who died of COVID-19. We reviewed light microscopy findings in all autopsies and performed immunofluorescence, electron microscopy, and in situ hybridization studies for SARS-CoV-2 on a subset of samples.

Results

The cohort had a median age of 71.5 years (range, 38-97 years); 69% were men, 57% were Hispanic, and 73% had a history of hypertension. Among patients with available data, AKI developed in 31 of

SUBMITTER: Santoriello D 

PROVIDER: S-EPMC7461662 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature