Novel approach to quantitative spatial gene expression uncovers genetic stochasticity in the developing Drosophila eye.

ABSTRACT: Robustness in development allows for the accumulation of genetically based variation in expression. However, this variation is usually examined in response to large perturbations, and examination of this variation has been limited to being spatial, or quantitative, but because of technical restrictions not both. Here we bridge these gaps by investigating replicated quantitative spatial gene expression using rigorous statistical models, in different genotypes, sexes, and species (Drosophila melanogaster and D. simulans). Using this type of quantitative approach with molecular developmental data allows for comparison among conditions, such as different genetic backgrounds. We apply this approach to the morphogenetic furrow, a wave of differentiation that patterns the developing eye disc. Wit

SUBMITTER: Ali S 

PROVIDER: S-EPMC7461728 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature