Human Regulatory Dendritic Cells Develop From Monocytes in Response to Signals From Regulatory and Helper T Cells.

ABSTRACT: Dendritic cells (DCs) are powerful antigen presenting cells, derived from bone marrow progenitors (cDCs) and monocytes (moDCs), that can shape the immune response by priming either proinflammatory or tolerogenic immune effector cells. The cellular mechanisms responsible for the generation of DCs that will prime a proinflammatory or tolerogenic response are poorly understood. Here we describe a novel mechanism by which tolerogenic DCs are formed from monocytes. When human monocytes were cultured with CD4⁺FoxP3⁺ natural regulatory T cells (Tregs) and T helper cells (Th) from healthy donor blood, they differentiated into regulatory DCs (DC _Reg ), capable of generating induced Tregs from naïve T cells. DC _Reg exhibited morphology, surfa

SUBMITTER: Zhang X 

PROVIDER: S-EPMC7461788 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature