Effector CD8 T Cell-Dependent Zika Virus Control in the CNS: A Matter of Time and Numbers.

ABSTRACT: Zika virus (ZIKV), a mosquito-borne flavivirus, came into the spotlight in 2016 when it was found to be associated with an increased rate of microcephalic newborns in Brazil. The virus has further been recognized to cause neurologic complications in children and adults in the form of myelitis, encephalitis, acute disseminated encephalomyelitis (ADEM) and Guillain Barre Syndrome in a fraction of infected individuals. With the ultimate goal of identifying correlates of protection to guide the design of an effective vaccine, the study of the immune response to ZIKV infection has become the focus of research worldwide. Both innate and adaptive immune responses seem to be essential for controlling the infection. Induction of sufficient levels of neutralizing antibodies has been strongly correla

SUBMITTER: Nazerai L 

PROVIDER: S-EPMC7461798 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature