Advances in hematopoietic cell transplant for the treatment of hematologic malignancies.

ABSTRACT:

Purpose of review

Incorporation of minimal residual disease (MRD) testing in acute lymphoblastic leukemia (ALL) and acute myeloblastic leukemia (AML) has transformed the landscape of hematopoietic cell transplantation (HCT). Pre-HCT MRD has allowed prognostication of HCT outcomes for high-risk leukemia patients, whereas the detection of post-HCT MRD has allowed for interventions to decrease relapse.

Recent findings

In this review, we emphasize studies from the past two decades that highlight the critical role of MRD in HCT in pediatric ALL and AML. Advances in MRD detection methodology, using next-generation sequencing, have improved the sensitivity of MRD testing allowing for more accurate predictions of HCT outcomes for patients with relapsed and refractory ALL and AML. In

SUBMITTER: Taraseviciute A 

PROVIDER: S-EPMC7461816 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature