Epigenetic Regulation of Airway Epithelium Immune Functions in Asthma.

ABSTRACT: Asthma is a chronic inflammatory disease of the respiratory tract characterized by recurrent breathing problems resulting from airway obstruction and hyperresponsiveness. Human airway epithelium plays an important role in the initiation and control of the immune responses to different types of environmental factors contributing to asthma pathogenesis. Using pattern recognition receptors airway epithelium senses external stimuli, such as allergens, microbes, or pollutants, and subsequently secretes endogenous danger signaling molecules alarming and activating dendritic cells. Hence, airway epithelial cells not only mediate innate immune responses but also bridge them with adaptive immune responses involving T and B cells that play a crucial role in the pathogenesis of asthma. The effects of

SUBMITTER: Alashkar Alhamwe B 

PROVIDER: S-EPMC7461869 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature