Immune Tolerance Induction Using Cell-Based Strategies in Liver Transplantation: Clinical Perspectives.

ABSTRACT: Liver transplantation (LT) has become the best chance and a routine practice for patients with end-stage liver disease and small hepatocellular carcinoma. However, life-long immunosuppressive regimens could lead to many post-LT complications, including cancer recurrence, infections, dysmetabolic syndrome, and renal injury. Impeccable management of immunosuppressive regimens is indispensable to ensure the best long-term prognosis for LT recipients. This is challenging for these patients, who probably have a post-LT graft survival of more than 10 or even 20 years. Approximately 20% of patients after LT could develop spontaneous operational tolerance. They could maintain normal graft function and histology without any immunosuppressive regimens. Operational tolerance after transplantation has

SUBMITTER: Wang P 

PROVIDER: S-EPMC7461870 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature