Otic Neurogenesis Is Regulated by TGFβ in a Senescence-Independent Manner.

ABSTRACT: Cellular senescence has classically been associated with aging. Intriguingly, recent studies have also unraveled key roles for senescence in embryonic development, regeneration, and reprogramming. Developmental senescence has been reported during embryonic development in different organisms and structures, such as the endolymphatic duct during inner ear development of mammals and birds. However, there is no study addressing the possible role of senescence on otic neurogenesis. TGFβ/SMAD is the best-known pathway linked to the induction of developmentally programmed cell senescence. Here, we studied if TGFβ2 induces cellular senescence during acoustic-vestibular-ganglion (AVG) formation. Using organotypic cultures of AVG, and characterizing different stages of otic neurogenesis in the prese

SUBMITTER: Magarinos M 

PROVIDER: S-EPMC7461926 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature