Smaller total brain volume but not subcortical structure volume related to common genetic risk for ADHD.

ABSTRACT:

Background

Mechanistic endophenotypes can inform process models of psychopathology and aid interpretation of genetic risk factors. Smaller total brain and subcortical volumes are associated with attention-deficit hyperactivity disorder (ADHD) and provide clues to its development. This study evaluates whether common genetic risk for ADHD is associated with total brain volume (TBV) and hypothesized subcortical structures in children.

Methods

Children 7-15 years old were recruited for a case-control study (N = 312, N = 199 ADHD). Children were assessed with a multi-informant, best-estimate diagnostic procedure and motion-corrected MRI measured brain volumes. Polygenic scores were computed based on discovery data from the Psychiatric Genomics Consortium (N =

SUBMITTER: Mooney MA 

PROVIDER: S-EPMC7461955 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature