Effects of teriparatide and bisphosphonate on spinal fusion procedure: A systematic review and network meta-analysis.

ABSTRACT:

Background

Giving patients anti-osteoporotic agents peri-operatively is a well-accepted strategy to increase fusion rate and prevent complications. The purpose of this study was to investigate effectiveness of teriparatide and bisphosphonate on fusion surgery of thoracic and lumbar spine.

Methods

We searched EMBASE and PubMed for randomized clinical trials (RCTs) and prospective comparative studies using teriparatide or bisphosphonate in peri-operative spinal fusion surgery. Our synthesized data of fusion rate, Oswestry disability index (ODI), and adverse event in contrast-based network meta-analysis. Pooled results were presented in risk ratio (RR) or mean difference (MD) with 95% confidence interval (CI).

Results

Our search hit eight RCTs and three prospective studi

SUBMITTER: Cheng SH 

PROVIDER: S-EPMC7462270 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature