Ontology highlight
ABSTRACT:
SUBMITTER: Giamarellos-Bourboulis EJ
PROVIDER: S-EPMC7462457 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Cell 20200901 2
BCG vaccination in children protects against heterologous infections and improves survival independently of tuberculosis prevention. The phase III ACTIVATE trial assessed whether BCG has similar effects in the elderly. In this double-blind, randomized trial, elderly patients (n = 198) received BCG or placebo vaccine at hospital discharge and were followed for 12 months for new infections. At interim analysis, BCG vaccination significantly increased the time to first infection (median 16 weeks co ...[more]