Ontology highlight
ABSTRACT:
SUBMITTER: Giamarellos-Bourboulis EJ
PROVIDER: S-EPMC7462457 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Giamarellos-Bourboulis Evangelos J EJ Tsilika Maria M Moorlag Simone S Antonakos Nikolaos N Kotsaki Antigone A Domínguez-Andrés Jorge J Kyriazopoulou Evdoxia E Gkavogianni Theologia T Adami Maria-Evangelia ME Damoraki Georgia G Koufargyris Panagiotis P Karageorgos Athanassios A Bolanou Amalia A Koenen Hans H van Crevel Reinout R Droggiti Dionyssia-Irene DI Renieris George G Papadopoulos Antonios A Netea Mihai G MG
Cell 20200901 2
BCG vaccination in children protects against heterologous infections and improves survival independently of tuberculosis prevention. The phase III ACTIVATE trial assessed whether BCG has similar effects in the elderly. In this double-blind, randomized trial, elderly patients (n = 198) received BCG or placebo vaccine at hospital discharge and were followed for 12 months for new infections. At interim analysis, BCG vaccination significantly increased the time to first infection (median 16 weeks co ...[more]