Association of serum uromodulin with mortality and cardiovascular disease in the elderly-the Cardiovascular Health Study.

ABSTRACT:

Background

Uromodulin (UMOD) is released by renal tubular cells into the serum (sUMOD) and urine. Lower urine UMOD has been linked to mortality and cardiovascular disease but much less is known about sUMOD. We evaluated the association of sUMOD with these outcomes in community-dwelling older adults.

Methods

We measured sUMOD in a random subcohort of 933 participants enrolled in the Cardiovascular Health Study. The associations of sUMOD with all-cause mortality, incident heart failure (HF) and incident cardiovascular disease (CVD; myocardial infarction, stroke and mortality due to coronary disease or stroke) were evaluated using multivariable Cox regression, adjusting for study participants' demographics, estimated glomerular filtration rate (eGFR), albuminuria and CVD risk f

SUBMITTER: Steubl D 

PROVIDER: S-EPMC7462724 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature