Mendelian randomization analyses of genetically predicted circulating levels of cytokines with risk of breast cancer.

ABSTRACT: To determine whether genetically predicted circulating levels of cytokines are associated with risk of overall breast cancer (BC), estrogen receptor (ER)-positive and ER-negative BC, we conducted two-sample MR analyses using data from the most comprehensive genome-wide association studies (GWAS) on cytokines in 8293 Finnish participants and the largest BC GWAS from the Breast Cancer Association Consortium (BCAC) with totally 122,977 BC cases and 105,974 healthy controls. We systematically screened 41 cytokines (of which 24 cytokines have available instruments) and identified that genetically predicted circulating levels (1-SD increase) of MCP1 (OR: 1.08; 95% CIs: 1.03-1.12; P value: 3.55 × 10^-4), MIP1b (OR: 1.02; 95% CIs: 1.01-1.04; P value: 2.70 × 10^-3)

SUBMITTER: Li S 

PROVIDER: S-EPMC7462857 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature