¹H, ¹⁵N and ¹³C resonance assignments of the HR1c domain of PRK1, a protein kinase C-related kinase.

ABSTRACT: PRK1 is a member of the protein kinase C-related kinase (PRK) family of serine/threonine kinases and a downstream effector of Rho GTPases. PRK1 has three N-terminal Homology Region 1 (HR1) domains (HR1a, HR1b and HR1c), which form antiparallel coiled coils that interact with Rho family GTPases. PRK1 also has a C2-like domain that targets it to the plasma membrane and a kinase domain, which is a member of the protein kinase C superfamily. PRK1 is involved in cytoskeletal regulation, cell adhesion, cell cycle progression and the immune response, and is implicated in cancer. There is currently no structural information for the HR1c domain. The ¹H, ¹⁵N and ¹³C NMR backbone and sidechain resonance assignment of the HR1c domain presented here forms the basis for

SUBMITTER: Sophocleous G 

PROVIDER: S-EPMC7462907 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature