Differential contribution of bone marrow-derived infiltrating monocytes and resident macrophages to persistent lung inflammation in chronic air pollution exposure.

ABSTRACT: Chronic exposure to particulate matter < 2.5µ (PM_2.5) has been linked to cardiopulmonary disease. Tissue-resident (TR) alveolar macrophages (AΦ) are long-lived, self-renew and critical to the health impact of inhalational insults. There is an inadequate understanding of the impact of PM_2.5 exposure on the nature/time course of transcriptional responses, self-renewal of AΦ, and the contribution from bone marrow (BM) to this population. Accordingly, we exposed chimeric (CD45.2/CD45.1) mice to concentrated PM_2.5 or filtered air (FA) to evaluate the impact on these end-points. PM_2.5 exposure for 4-weeks induced an influx of BM-derived monocytes into the lungs with no contribution to the overall TR-AΦ pool. Chronic (32-weeks) PM_2.5 exposure

SUBMITTER: Gangwar RS 

PROVIDER: S-EPMC7462977 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature