Genetic polymorphisms associated with telomere length and risk of developing myeloproliferative neoplasms.

ABSTRACT: Telomere length measured in leukocyte (LTL) has been found to be associated with the risk of developing several cancer types, including myeloproliferative neoplasms (MPNs). LTL is genetically determined by, at least, 11 SNPs previously shown to influence LTL. Their combination in a score has been used as a genetic instrument to measure LTL and evaluate the causative association between LTL and the risk of several cancer types. We tested, for the first time, the "teloscore" in 480 MPN patients and 909 healthy controls in a European multi-center case-control study. We found an increased risk to develop MPNs with longer genetically determined telomeres (OR = 1.82, 95% CI 1.24-2.68, P = 2.21 × 10^-3, comparing the highest with the lowest quintile of the teloscore distribution). Analy

SUBMITTER: Giaccherini M 

PROVIDER: S-EPMC7463014 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature