Is oseltamivir suitable for fighting against COVID-19: In silico assessment, in vitro and retrospective study.

ABSTRACT:

Background

Oseltamivir is a first-line antiviral drug, especially in primary hospitals. During the ongoing outbreak of coronavirus disease 2019 (COVID-19), most patients with COVID-19 who are symptomatic have used oseltamivir. Considering its popular and important role as an antiviral drug, it is necessary to evaluate oseltamivir in the treatment of COVID-19.

Objective

To evaluate the effect of oseltamivir against COVID-19.

Methods

Swiss-model was used to construct the structure of the N-terminal RNA-binding domain (NRBD) of the nucleoprotein (NC), papain-like protease (PLpro), and RNA-directed RNA polymerase (RdRp) of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). TM-align program was performed to compare the structure of the viral proteins with the st

SUBMITTER: Tan Q 

PROVIDER: S-EPMC7463036 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature