Distinct temporal trends in breast cancer incidence from 1997 to 2016 by molecular subtypes: a population-based study of Scottish cancer registry data.

ABSTRACT:

Background

We describe temporal trends in breast cancer incidence by molecular subtypes in Scotland because public health prevention programmes, diagnostic and therapeutic services are shaped by differences in tumour biology.

Methods

Population-based cancer registry data on 72,217 women diagnosed with incident primary breast cancer from 1997 to 2016 were analysed. Age-standardised rates (ASR) and age-specific incidence were estimated by tumour subtype after imputing the 8% of missing oestrogen receptor (ER) status. Joinpoint regression and age-period-cohort models were used to assess whether significant differences were observed in incidence trends by ER status.

Results

Overall, ER-positive tumour incidence increased by 0.4%/year (95% confidence interval (CI): -0.1, 1

SUBMITTER: Mesa-Eguiagaray I 

PROVIDER: S-EPMC7463252 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature