Waning vaccine protection against influenza A (H3N2) illness in children and older adults during a single season.

ABSTRACT:

Background

Recent studies have suggested that vaccine-induced protection against influenza may decline within one season. We reanalyzed data from a study of influenza vaccine effectiveness to determine if time since vaccination was an independent predictor of influenza A (H3N2).

Methods

Patients with acute respiratory illness were actively recruited during the 2007-2008 season. Respiratory swabs were tested for influenza, and vaccination dates were determined by a validated immunization registry. The association between influenza RT-PCR result and vaccination interval (days) was examined using multivariable logistic regression, adjusting for calendar time, age and other confounders.

Results

There were 629 vaccinated participants, including 177 influenza A (H3N2) cases

SUBMITTER: Belongia EA 

PROVIDER: S-EPMC7463277 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature