The benefits of smoking cessation on survival in cancer patients by integrative analysis of multi-omics data.

ABSTRACT: Few studies have examined the association between smoking status (including former smokers) at diagnosis and overall survival among cancer patients. We aimed to assess the benefits of quitting smoking on cancer prognosis in cohorts of cancer patient smokers obtained from the Cancer Genome Atlas (TCGA) database. Hazard ratios (HR) were calculated to evaluate smoking behavior at cancer diagnosis (reformed smokers vs. current smokers) in association with overall survival using multivariate-adjusted Cox regressions analysis. According to our analyses, quitting smoking was the independent protective factor for overall survival in lung squamous cell carcinoma (LUSC) (HR = 0.67, 95% CI = 0.48-0.94). Comprehensive analysis of multicomponent data across reformed and current smokers identified a tot

SUBMITTER: Yang S 

PROVIDER: S-EPMC7463331 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature