Overexpression of Extradomain-B Fibronectin is Associated with Invasion of Breast Cancer Cells.

ABSTRACT: Breast tumor heterogeneity is a major impediment to oncotherapy. Cancer cells undergo rapid clonal evolution, thereby acquiring significant growth and invasive advantages. The absence of specific markers of these high-risk populations precludes efficient therapeutic and diagnostic management of the disease. Given the critical function of tumor microenvironment in the oncogenic circuitry, we sought to determine the expression profile of the extracellular matrix oncoprotein, extradomain-B fibronectin (EDB-FN) in invasive breast cancer. Analyses of TCGA/GTEx databases and immunostaining of clinical samples found a significant overexpression of EDB-FN in breast tumors, which correlated with poor overall survival. Significant upregulation of EDB-FN was observed in invasive cell populations gene

SUBMITTER: Vaidya A 

PROVIDER: S-EPMC7463489 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature