Involvement of Differentially Expressed microRNAs in the PEGylated Liposome Encapsulated ¹⁸⁸Rhenium-Mediated Suppression of Orthotopic Hypopharyngeal Tumor.

ABSTRACT: Hypopharyngeal cancer (HPC) accounts for the lowest survival rate among all types of head and neck cancers (HNSCC). However, the therapeutic approach for HPC still needs to be investigated. In this study, a theranostic ¹⁸⁸Re-liposome was prepared to treat orthotopic HPC tumors and analyze the deregulated microRNA expressive profiles. The therapeutic efficacy of ¹⁸⁸Re-liposome on HPC tumors was evaluated using bioluminescent imaging followed by next generation sequencing (NGS) analysis, in order to address the deregulated microRNAs and associated signaling pathways. The differentially expressed microRNAs were also confirmed using clinical HNSCC samples and clinical information from The Cancer Genome Atlas (TCGA) database. Repeated doses of ¹⁸⁸Re-liposome wer

SUBMITTER: Lin BZ 

PROVIDER: S-EPMC7463599 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature