Pan-Cancer Analysis of the Genomic Alterations and Mutations of the Matrisome.

ABSTRACT: The extracellular matrix (ECM) is a master regulator of all cellular functions and a major component of the tumor microenvironment. We previously defined the "matrisome" as the ensemble of genes encoding ECM proteins and proteins modulating ECM structure or function. While compositional and biomechanical changes in the ECM regulate cancer progression, no study has investigated the genomic alterations of matrisome genes in cancers and their consequences. Here, mining The Cancer Genome Atlas (TCGA) data, we found that copy number alterations and mutations are frequent in matrisome genes, even more so than in the rest of the genome. We also found that these alterations are predicted to significantly impact gene expression and protein function. Moreover, we identified matrisome genes whose mut

SUBMITTER: Izzi V 

PROVIDER: S-EPMC7463652 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature