Ontology highlight
ABSTRACT:
SUBMITTER: Gambelunghe A
PROVIDER: S-EPMC7463694 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Gambelunghe Angela A Giovagnoli Stefano S Di Michele Alessandro A Boncompagni Simona S Dell'Omo Marco M Leopold Kerstin K Iavicoli Ivo I Talesa Vincenzo Nicola VN Antognelli Cinzia C
Antioxidants (Basel, Switzerland) 20200803 8
Gold nanoparticles (AuNPs) are considered nontoxic upon acute exposure, at least when they are equal or above 5 nm size. However, the safeguard mechanisms contributing to maintain cell viability are scarcely explored so far. Here, we investigated the cyto-protective role of Glyoxalase 1 (Glo1), a key enzyme involved in the control of deleterious dicarbonyl stress, in two human cell types of the respiratory tract, after an acute exposure to AuNPs with a main size of 5 nm. We found that the redox ...[more]