Mitochondrial HMG-Box Containing Proteins: From Biochemical Properties to the Roles in Human Diseases.

ABSTRACT: Mitochondrial DNA (mtDNA) molecules are packaged into compact nucleo-protein structures called mitochondrial nucleoids (mt-nucleoids). Their compaction is mediated in part by high-mobility group (HMG)-box containing proteins (mtHMG proteins), whose additional roles include the protection of mtDNA against damage, the regulation of gene expression and the segregation of mtDNA into daughter organelles. The molecular mechanisms underlying these functions have been identified through extensive biochemical, genetic, and structural studies, particularly on yeast (Abf2) and mammalian mitochondrial transcription factor A (TFAM) mtHMG proteins. The aim of this paper is to provide a comprehensive overview of the biochemical properties of mtHMG proteins, the structural basis of their interaction with

SUBMITTER: Vozarikova V 

PROVIDER: S-EPMC7463775 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature