Polymyxins and Bacterial Membranes: A Review of Antibacterial Activity and Mechanisms of Resistance.

ABSTRACT: Following their initial discovery in the 1940s, polymyxin antibiotics fell into disfavor due to their potential clinical toxicity, especially nephrotoxicity. However, the dry antibiotic development pipeline, together with the rising global prevalence of infections caused by multidrug-resistant (MDR) Gram-negative bacteria have both rejuvenated clinical interest in these polypeptide antibiotics. Parallel to the revival of their use, investigations into the mechanisms of action and resistance to polymyxins have intensified. With an initial known effect on biological membranes, research has uncovered the detailed molecular and chemical interactions that polymyxins have with Gram-negative outer membranes and lipopolysaccharide structure. In addition, genetic and epidemiological studies have re

SUBMITTER: Ayoub Moubareck C 

PROVIDER: S-EPMC7463838 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature