Structure-Antifouling Activity Relationship and Molecular Targets of Bio-Inspired(thio)xanthones.

ABSTRACT: The development of alternative ecological and effective antifouling technologies is still challenging. Synthesis of nature-inspired compounds has been exploited, given the potential to assure commercial supplies of potential ecofriendly antifouling agents. In this direction, the antifouling activity of a series of nineteen synthetic small molecules, with chemical similarities with natural products, were exploited in this work. Six (4, 5, 7, 10, 15 and 17) of the tested xanthones showed in vivo activity toward the settlement of Mytilus galloprovincialis larvae (EC₅₀: 3.53-28.60 µM) and low toxicity to this macrofouling species (LC₅₀ > 500 µM and LC₅₀/EC₅₀: 17.42-141.64), and two of them (7 an

SUBMITTER: Almeida JR 

PROVIDER: S-EPMC7463931 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature