Comparative In Vitro Toxicology of Novel Cytoprotective Short-Chain Naphthoquinones.

ABSTRACT: Short-chain quinones (SCQs) have been identified as potential drug candidates against mitochondrial dysfunction, which largely depends on the reversible redox characteristics of the active quinone core. We recently identified 11 naphthoquinone derivatives, 1-11, from a library of SCQs that demonstrated enhanced cytoprotection and improved metabolic stability compared to the clinically used benzoquinone idebenone. Since the toxicity properties of our promising SCQs were unknown, this study developed multiplex methods and generated detailed toxicity profiles from 11 endpoint measurements using the human hepatocarcinoma cell line HepG2. Overall, the toxicity profiles were largely comparable across different assays, with simple standard assays showing increased sensitivity compar

SUBMITTER: Feng Z 

PROVIDER: S-EPMC7463972 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature