Rapid Fabrication of Membrane-Integrated Thermoplastic Elastomer Microfluidic Devices.

ABSTRACT: Leveraging the advantageous material properties of recently developed soft thermoplastic elastomer materials, this work presents the facile and rapid fabrication of composite membrane-integrated microfluidic devices consisting of FlexdymTM polymer and commercially available porous polycarbonate membranes. The three-layer devices can be fabricated in under 2.5 h, consisting of a 2-min hot embossing cycle, conformal contact between device layers and a low-temperature baking step. The strength of the FlexdymTM-polycarbonate seal was characterized using a specialized microfluidic delamination device and an automated pressure controller configuration, offering a standardized and high-throughput method of microfluidic burst testing. Given a minimum bonding distance of 200 μm, the materials showe

SUBMITTER: McMillan AH 

PROVIDER: S-EPMC7463978 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature