Thiourea-Derived Chelating Ligands and Their Organometallic Compounds: Investigations into Their Anticancer Activity.

ABSTRACT: Thiones have been investigated as ligands in metal complexes with catalytic and biological activity. We report the synthesis, characterization, and biological evaluation of a series of M^II/III complexes of the general formulae [M^II(cym)(L)Cl]X (cym = η⁶-p-cymene) or [M^III(Cp*)(L)Cl]X (Cp* = η⁵-pentamethylcyclopentadienyl), where X = Cl^- or PF₆^-, and L represents heterocyclic derivatives of thiourea. The thiones feature a benzyl-triazolyl pendant and they act as bidentate ligands via N,S-coordination to the metal centers. Several derivatives have been investigated by single-crystal X-ray diffraction analysis. NMR investigations showed a counterion-dependent shift of several protons d

SUBMITTER: Tong KKH 

PROVIDER: S-EPMC7464268 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature