Sex-Specific Transcriptome Differences in Human Adipose Mesenchymal Stem Cells.

ABSTRACT: In humans, sexual dimorphism can manifest in many ways and it is widely studied in several knowledge fields. It is increasing the evidence that also cells differ according to sex, a correlation still little studied and poorly considered when cells are used in scientific research. Specifically, our interest is on the sex-related dimorphism on the human mesenchymal stem cells (hMSCs) transcriptome. A systematic meta-analysis of hMSC microarrays was performed by using the Transcriptome Mapper (TRAM) software. This bioinformatic tool was used to integrate and normalize datasets from multiple sources and allowed us to highlight chromosomal segments and genes differently expressed in hMSCs derived from adipose tissue (hADSCs) of male and female donors. Chromosomal segments and differentially exp

SUBMITTER: Bianconi E 

PROVIDER: S-EPMC7464371 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature