Oxidative Stress Response Is Mediated by Overexpression and Spatiotemporal Regulation of Caveolin-1.

ABSTRACT: Oxidative stress (OS) has been linked to the aetiology of many diseases including osteoarthritis (OA). Recent studies have shown that caveolin-1-a structural protein of plasma membrane's caveolae-is upregulated in response to OS. Here, we explore the function of caveolin-1 in chondrocytes derived from healthy individuals (control) and OA patients that were subjected to exogenous OS. We showed that caveolin-1 was upregulated in response to acute OS in the control, but not in OA chondrocytes. Moreover, OS-induced DNA damage analysis revealed that control cells started repairing the DNA lesions 6 h post-oxidative treatment, while OA cells seemed unable to restore these damages. Importantly, in the control cells, we observed a translocation of caveolin-1 from the membrane/cytoplasm in and out

SUBMITTER: Goutas A 

PROVIDER: S-EPMC7464519 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature