Antibody-Drug Conjugates: A Promising Novel Therapy for the Treatment of Ovarian Cancer.

ABSTRACT: Antibody-drug conjugates (ADCs) represent a novel and promising therapeutic strategy for the treatment of cancer patients. ADCs target antigens highly expressed on the membrane surface of tumor cells to selectively deliver a cytotoxic drug. Ovarian tumors differentially express tumor-specific antigens, which can be used to guide ADCs. This strategy allows for optimizing tumor targeting while minimizing systemic toxicity compared to classical chemotherapeutic agents. ADCs can be improved by using a cleavable linker allowing the delivery of the toxic payload in surrounding cells not expressing the target protein, therefore acting on heterogeneous tumors with different cell populations. Currently, more than 15 ADCs are under preclinical investigation in ovarian cancer, and some of them have a

SUBMITTER: Manzano A 

PROVIDER: S-EPMC7464539 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature