CD160 Stimulates CD8⁺ T Cell Responses and Is Required for Optimal Protective Immunity to Listeria monocytogenes.

ABSTRACT: CD160 promotes NK cell cytotoxicity and IFN-γ production, but the function of CD160 on CD8⁺ T cells remains unclear with some studies supporting a coinhibitory role and others a costimulatory role. In this study, we demonstrate that CD160 has a costimulatory role in promoting CD8⁺ T cell effector functions needed for optimal clearance of oral Listeria monocytogenes infection. CD160^-/- mice did not clear oral L. monocytogenes as efficiently as wild type (WT) littermates. WT RAG^-/- and CD160^-/- RAG^-/- mice similarly cleared L. monocytogenes, indicating that CD160 on NK cells does not contribute to impaired L. monocytogenes clearance. Defective L. monocytogenes clearance is due to compromised

SUBMITTER: Tan CL 

PROVIDER: S-EPMC7464592 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature