Fibroblastic reticular cells enhance T cell metabolism and survival via epigenetic remodeling.

ABSTRACT: Lymph node fibroblastic reticular cells (FRCs) respond to signals from activated T cells by releasing nitric oxide, which inhibits T cell proliferation and restricts the size of the expanding T cell pool. Whether interactions with FRCs also support the function or differentiation of activated CD8⁺ T cells is not known. Here we report that encounters with FRCs enhanced cytokine production and remodeled chromatin accessibility in newly activated CD8⁺ T cells via interleukin-6. These epigenetic changes facilitated metabolic reprogramming and amplified the activity of pro-survival pathways through differential transcription factor activity. Accordingly, FRC conditioning significantly enhanced the persistence of virus-specific CD8⁺ T cells in vivo and augmented

SUBMITTER: Brown FD 

PROVIDER: S-EPMC7464610 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature