Ontology highlight
ABSTRACT:
SUBMITTER: Anisenko A
PROVIDER: S-EPMC7464883 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Anisenko Andrey A Kan Marina M Shadrina Olga O Brattseva Anna A Gottikh Marina M
Cells 20200816 8
The DNA dependent protein kinase (DNA-PK) is a trimeric nuclear complex consisting of a large protein kinase and the Ku heterodimer. The kinase activity of DNA-PK is required for efficient repair of DNA double-strand breaks (DSB) by non-homologous end joining (NHEJ). We also showed that the kinase activity of DNA-PK is essential for post-integrational DNA repair in the case of HIV-1 infection. Besides, DNA-PK is known to participate in such cellular processes as protection of mammalian telomeres ...[more]