Molecular Mechanisms of AKI in the Elderly: From Animal Models to Therapeutic Intervention.

ABSTRACT: Acute kidney injury (AKI), a critical syndrome characterized by a sudden reduction of renal function, is a common disorder among elderly patients particularly in Intensive Care Unit (ICU). AKI is closely associated with both short- and long-term mortality and length of hospital stay and is considered a predictor of chronic kidney disease (CKD). Specific hemodynamic, metabolic, and molecular changes lead to increased susceptibility to injury in the aged kidney; therefore, certain causes of AKI such as the prerenal reduction in renal perfusion or vascular obstructive conditions are more common in the elderly; moreover, AKI is often multifactorial and iatrogenic. Older patients present several comorbidities (diabetes, hypertension, heart failure) and are exposed to multiple medical interventi

SUBMITTER: Infante B 

PROVIDER: S-EPMC7464895 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature