Early Intervention in Ulcerative Colitis: Ready for Prime Time?

ABSTRACT: Growing evidence shows that ulcerative colitis (UC) is a progressive disease similar to Crohn's disease (CD). The UC-related burden is often underestimated by physicians and a standard step-up therapeutic approach is preferred. However, in many patients with UC the disease activity is not adequately controlled by current management, leading to poor long-term prognosis. Data from both randomized controlled trials and real-world studies support early intervention in CD in order to prevent disease progression and irreversible bowel damage. Similarly, an early disease intervention during the so-called "window of opportunity" could lead to better outcomes in UC. Here, we summarize the literature evidence on early intervention in patients with UC, highlighting strengths and limitations of this a

SUBMITTER: Solitano V 

PROVIDER: S-EPMC7464940 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature