Stemness Potency of Human Gingival Cells-Application in Anticancer Therapies and Clinical Trials.

ABSTRACT: Gingivae, as the part of periodontium, are involved in tooth support and possess the ability to heal rapidly, without scar formation. Recently, dental tissues have been identified as a potential source of mesenchymal stem cells (MSCs) and several populations of MSCs were isolated from the orofacial region, including gingival mesenchymal stem cells (GMSCs). GMSCs exhibit robust immunomodulatory and differentiation potential and are easily obtainable, which make them promising candidates for cellular therapies. Apart from being tested for application in immunologic- and inflammatory-related disorders and various tissue regeneration, GMSCs promise to be a valuable tool in cancer treatment, especially in tongue squamous cell carcinoma (TSCC) with the use of targeted therapy, since GMSCs are ab

SUBMITTER: Stefanska K 

PROVIDER: S-EPMC7464983 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature